{"id":1149,"date":"2016-05-20T15:49:50","date_gmt":"2016-05-20T03:49:50","guid":{"rendered":"http:\/\/www.frot.co.nz\/design\/dietnet\/?p=1149"},"modified":"2021-05-18T09:39:51","modified_gmt":"2021-05-17T21:39:51","slug":"antibiotics-that-kill-gut-bacteria-also-stop-growth-of-new-brain-cells","status":"publish","type":"post","link":"http:\/\/www.frot.co.nz\/design\/dietnet\/2016\/05\/20\/antibiotics-that-kill-gut-bacteria-also-stop-growth-of-new-brain-cells\/","title":{"rendered":"Antibiotics that kill gut bacteria also stop growth of new brain cells"},"content":{"rendered":"
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\u00a0Antibiotics strong enough to kill off gut bacteria can also stop the growth of new brain cells in the hippocampus, a section of the brain associated with memory, reports a new study in mice. Researchers also uncovered a clue to why \u2014 a type of white blood cell seems to act as a communicator between the brain, the immune system, and the gut.<\/p>\n

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Antibiotics strong enough to kill off gut bacteria can also stop the growth of new brain cells in the hippocampus, a section of the brain associated with memory, reports a study in mice published May 19 in Cell Reports. Researchers also uncovered a clue to why\u2013 a type of white blood cell seems to act as a communicator between the brain, the immune system, and the gut.<\/p>\n

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\u201cWe found prolonged antibiotic treatment might impact brain function,\u201d says senior author Susanne Asu Wolf of the Max-Delbrueck-Center for Molecular Medicine in Berlin, Germany. \u201cBut probiotics and exercise can balance brain plasticity and should be considered as a real treatment option.\u201d<\/p>\n

Wolf first saw clues that the immune system could influence the health and growth of brain cells through research into T cells nearly 10 years ago. But there were few studies that found a link from the brain to the immune system and back to the gut.<\/p>\n

In the new study, the researchers gave a group of mice enough antibiotics for them to become nearly free of intestinal microbes. Compared to untreated mice, the mice who lost their healthy gut bacteria performed worse in memory tests and showed a loss of neurogenesis (new brain cells) in a section of their hippocampus that typically produces new brain cells throughout an individual\u2019s lifetime. At the same time that the mice experienced memory and neurogenesis loss, the research team detected a lower level of white blood cells (specifically monocytes) marked with Ly6Chi in the brain, blood, and bone marrow. So researchers tested whether it was indeed the Ly6Chi monocytes behind the changes in neurogenesis and memory.<\/p>\n

In another experiment, the research team compared untreated mice to mice that had healthy gut bacteria levels but low levels of Ly6Chi either due to genetics or due to treatment with antibodies that target Ly6Chi cells. In both cases, mice with low Ly6Chi levels showed the same memory and neurogenesis deficits as mice in the other experiment who had lost gut bacteria. Furthermore, if the researchers replaced the Ly6Chi levels in mice treated with antibiotics, then memory and neurogenesis improved.<\/p>\n

\u201cFor us it was impressive to find these Ly6Chi cells that travel from the periphery to the brain, and if there\u2019s something wrong in the microbiome, Ly6Chi acts as a communicating cell,\u201d says Wolf.<\/p>\n

Luckily, the adverse side effects of the antibiotics could be reversed. Mice who received probiotics or who exercised on a wheel after receiving antibiotics regained memory and neurogenesis. \u201cThe magnitude of the action of probiotics on Ly6Chi cells, neurogenesis, and cognition impressed me,\u201d she says.<\/p>\n

But one result in the experiment raised more questions about the gut\u2019s bacteria and the link between Ly6Chi and the brain. While probiotics helped the mice regain memory, fecal transplants to restore a healthy gut bacteria did not have an effect.<\/p>\n

\u201cIt was surprising that the normal fecal transplant recovered the broad gut bacteria, but did not recover neurogenesis,\u201d says Wolf. \u201cThis might be a hint towards direct effects of antibiotics on neurogenesis without using the detour through the gut. To decipher this we might treat germ free mice without gut flora with antibiotics and see what is different.\u201d<\/p>\n

In the future, researchers also hope to see more clinical trials investigating whether probiotic treatments will improve symptoms in patients with neurodegenerative and psychiatric disorders.\u201dWe could measure the outcome in mood, psychiatric symptoms, microbiome composition and immune cell function before and after probiotic treatment,\u201d says Wolf.<\/p>\n<\/div>\n

\u00a0https:\/\/www.sciencedaily.com\/releases\/2016\/05\/160519130105.htm<\/a><\/div>\n
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Journal Reference:<\/p>\n<\/div>\n

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  1. M\u00f6hle, Mattei, and Heimesaat et al. Ly6Chi Monocytes Provide a Link between Antibiotic-Induced Changes in Gut Microbiota and Adult Hippocampal Neurogenesis. Cell Reports, 2016 DOI: 10.1016\/j.celrep.2016.04.074<\/a>
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    \u00a0Antibiotics strong enough to kill off gut bacteria can also stop the growth of new brain cells in the hippocampus, a section of the brain associated with memory, reports a new study in mice. Researchers also uncovered a clue to why \u2014 a type of white blood cell seems to […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[35,41],"tags":[],"_links":{"self":[{"href":"http:\/\/www.frot.co.nz\/design\/dietnet\/wp-json\/wp\/v2\/posts\/1149"}],"collection":[{"href":"http:\/\/www.frot.co.nz\/design\/dietnet\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.frot.co.nz\/design\/dietnet\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.frot.co.nz\/design\/dietnet\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/www.frot.co.nz\/design\/dietnet\/wp-json\/wp\/v2\/comments?post=1149"}],"version-history":[{"count":4,"href":"http:\/\/www.frot.co.nz\/design\/dietnet\/wp-json\/wp\/v2\/posts\/1149\/revisions"}],"predecessor-version":[{"id":2154,"href":"http:\/\/www.frot.co.nz\/design\/dietnet\/wp-json\/wp\/v2\/posts\/1149\/revisions\/2154"}],"wp:attachment":[{"href":"http:\/\/www.frot.co.nz\/design\/dietnet\/wp-json\/wp\/v2\/media?parent=1149"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.frot.co.nz\/design\/dietnet\/wp-json\/wp\/v2\/categories?post=1149"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.frot.co.nz\/design\/dietnet\/wp-json\/wp\/v2\/tags?post=1149"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}