Americans drink over one hundred and forty-six billion cups of coffee per year.


Coffee plays a prominent role in the culinary and cultural landscape of the US and many other countries. Whether imbibed in the form of endless watery refills at greasy-spoon breakfast joints, or as a custom latte grabbed on the way to work, or as a concentrated espresso to cap a four-star dining experience, coffee has retained or even enhanced its status as “the most popular beverage after water.”1

In its most unprocessed form, coffee is a red (when ripe) cherry-like fruit, with the coffee bean found at the center. Precursors to modern coffee included a beverage made around 1000 AD with the whole fruit—both beans and hull—and a “wine-like concoction” made with the fermented pulp.2 Roasting of coffee beans began in the thirteenth century, setting the stage for today’s ubiquitous caffeinated beverage.

Coffee is an economic mover and shaker, second only to crude oil in its dominance of the global commodities market.3 Coffee exports, currently valued at over twenty billion dollars annually, are at record levels, although the surplus production has contributed to a two-year downward trend in prices that has squeezed the incomes of smaller producers.4 In the U.S., coffee shops are the fastest growing “niche” in the restaurant business, and Starbucks is the country’s third largest restaurant chain3 (without even counting the more than twenty-four thousand coffee shops operated by Starbucks International).5 As a leading purveyor of value-added coffee products, Starbucks’ net earnings (estimated at almost twenty-five billion dollars in 2018)6 have surpassed the monetary value of global coffee bean exports.

Per capita consumption of coffee is highest in countries such as Finland and Brazil, but Americans lead the world in total consumption, downing one hundred and forty-six billion cups of coffee per year.7 Roughly two-thirds of Americans (64 percent) drink at least one cup of coffee per day.8 Interestingly, employed adults consume more caffeinated beverages (including coffee) than unemployed adults.9 National studies looking broadly at dietary caffeine intake have showed that two-thirds of daily caffeine comes from coffee (with tea in second place), and—perhaps explaining Starbucks’ astronomical revenues—over half comes from “store-bought coffee.”9


Coffee contains more than eight hundred volatile compounds, including caffeine and chlorogenic acid (coffee’s primary polyphenolic compound).10 Caffeine is toxic to some insects and animals, notably herbivores.1 In humans, caffeine is a psychoactive substance and a central nervous system stimulant.11 In an upbeat video about coffee on the Smithsonian website,12 Sir Hans Kornberg (biochemistry professor at Boston University) explains the caffeine molecule’s stimulant effects as follows: ordinarily, something called “cyclic AMP” (a derivative of ATP, the primary molecule required for cellular energy) tells a cell’s machinery to “get moving;” when enough cyclic AMP has been made, “natural mechanisms” come along and call a halt to cyclic AMP production. Caffeine, however, overrides these natural mechanisms, removing the brake and allowing uninterrupted production of cyclic AMP.12 This “amped-up” production of cyclic AMP has been a known biological action of caffeine for decades.13 In lay terms, it means that coffee and caffeine “will cause the body to ‘forget’ that it is tired.”14

Many coffee drinkers celebrate the “alertness, elevated mood, wakefulness, increased speech and motor activity and decrease[d] appetite” that are the temporary hallmarks of their beverage of choice (and indeed, of all stimulants, whether natural or synthetic).15 The French author, Honoré de Balzac, is reputed to have been a major coffee habitué, consuming up to fifty cups a day when in the throes of writing his literary masterpieces.1 As Balzac’s coffee habit implies, caffeine’s ability to stimulate “pleasure and reward” centers in the brain makes it highly addictive; over time, an individual will need to take in ever more caffeine to achieve the same effects.16

Despite Balzac’s example, the founder of a modern company that trains Fortune 500 companies on emotional intelligence claimed in Forbes in 2012 that coffee is actually a “silent killer of success.”17 To explain this assertion, the Forbes author described a variety of undesirable caffeine-induced effects, including hyper-arousal; irritability, anxiety and other forms of emotional hijacking of behavior; rapid shallow breathing that “deprives the brain of the oxygen needed to keep your thinking calm and rational”; and decreased quality of sleep. With regard to the latter, he also noted that “caffeine has a six-hour half-life, which means it takes a full twenty-four hours to work its way out of your system.” A blogger writing for coffee fans concurs, admitting that coffee’s ability to keep drowsiness at bay “provides a short-term solution that creates a long-term problem.”14


Dr. Louisa Williams (author of Radical Medicine) characterizes caffeinated coffee as a “potent pharmacological agent” that can cause numerous harms (see Table 1).18 Williams encourages coffee drinkers to “gradually detoxify this drug from their bodies and lifestyle,” transitioning first to organic decaffeinated coffee, then switching to organic black or green tea and, finally, drinking herbal teas, beverages made from roasted chicory or simply warm water and lemon juice. (Note that decaffeinated coffee is not a desirable endpoint; it is neither entirely caffeine-free nor free of the other phytochemicals in coffee that can produce strong physiological effects.19)

After ingestion, caffeine is widely distributed throughout the body, “promptly” getting into all the body tissues and crossing the blood-brain, blood-placenta and blood-testis barriers.1 Williams observes that caffeine is a methyl-xanthine—a type of molecular compound that functions simultaneously as a stimulant “that can increase heart rate and blood flow” and as a relaxant “that can open blood vessels and loosen muscular tissues.”20 The stimulant property of methylxanthines is “one of the main reasons people often feel their hearts racing after consuming a lot of caffeinated foods or drinks.”20

Depletion of the adrenal glands and compromised nutrition and digestion are some of the many harmful effects of caffeine outlined by Williams.18 The adrenal glands govern the production of key hormones—including sex hormones, stress hormones such as cortisol and the neurotransmitters epinephrine, norepinephrine and dopamine. Williams and other holistically oriented medical practitioners note that coffee has extremely negative effects on this intricately balanced system. Coffee’s artificial stimulation of the adrenal glands and especially cortisol “means that every time you drink coffee, you’re activating the body’s fight-or-flight response,”21 putting your nervous system “on constant red alert” whether or not there is any actual stress.22 Normally, cortisol levels are high in the morning to help an individual “rise and shine for the day,” but when routine coffee consumption drives up cortisol artificially, it changes the pattern.21 Cortisol ends up being low in the morning instead of high—prompting the person to reach for a morning cup of coffee and perpetuating the topsy-turvy cycle until, finally, more severe adrenal fatigue sets in.23

Research has shown that coffee and caffeine affect utilization and absorption of key nutrients, for example, depleting magnesium and reducing absorption of iron.24 As a diuretic, caffeinated coffee also contributes to calcium excretion to such an extent that it “can add up to significant bone thinning.”25 Although some researchers rate this bone loss effect as “controversial,” one study found that elderly postmenopausal women who consumed about eighteen ounces of brewed coffee a day experienced “significantly higher rates of bone loss at the spine” compared to women with a lower daily intake.26 These effects on bone density prompted Colorado researchers in 2009 to recommend that premenopausal women limit their caffeine consumption to avoid osteoporosis.27

A couple of years ago, reflecting the current trendiness of anything to do with the microbiome, coffee lovers greeted a study published in Science28 with considerable fanfare. Although the study covered an extremely wide range of “intrinsic, environmental, dietary and medication parameters,” coffee enthusiasts pounced on the one sentence linking coffee, tea and wine to “a healthier and more diverse community of microbes living in the gut.”29 The researchers attributed this association to the three beverages’ high polyphenol content.28 Others, however, have suggested that coffee’s impact on the gut may not actually be beneficial. Dr. Edward Group of the Global Healing Center describes numerous undesirable effects on gut health, including a reduction in the stomach acid needed for digestion when morning coffee is consumed on an empty stomach (true for both caffeinated and decaffeinated coffee); a weakening of the stomach’s protective mucosal layer; acid reflux and esophageal changes resulting from coffee’s relaxation of the esophageal sphincter; aggravation of bowel disorders or an overactive bowel; and premature release of partially digested food into the small intestine, which can damage the intestinal wall and facilitate dysbiosis.24

Coffee drinkers who are interested in the microbiome might also want to bear in mind the results of a novel study of “coffee machine-associated bacteria” published in Scientific Reports30 and summarized in Scientific American, which found that nine in ten top-of-the-line espresso machines harbored “a whole menagerie of bacteria—including some pathogenic species more commonly associated with the toilet.”31 (About 30 percent of the world’s Michelin-starred restaurants feature the brand of espresso machine examined in the study.32) Given the discovery of bacteria with pathogenic properties “and the fast recovery of the [bacterial] communities after rinsing the capsule container,” the study’s authors advised “frequent maintenance” and preventing contact “of the coffee leach with other parts of the machine to avoid unintended contamination of the beverage.”30


Many researchers acknowledge the association of caffeine intake with “reversible and transient physiological effects broadly and cardiovascular effects specifically,” but surprisingly few are willing to pin any blame for more serious chronic health issues on coffee or caffeine.33 At the same time, some experts have called attention to caffeine’s potentially adverse effects on sleep or cardiovascular and other functions in “special” or “vulnerable” populations—broadly defined as “pregnant and lactating women, children and adolescents, young adults, and people with underlying heart or other health conditions, such as mental

Studies and meta-analyses (studies of studies) in humans have linked coffee consumption during pregnancy (including both caffeinated and decaffeinated brews in some studies) to an increased risk of pregnancy loss,35 preterm delivery36 and other adverse birth outcomes.37 A just-published long-term study of Irish mother-child pairs that looked at the effects of maternal consumption of both coffee and tea found “robust” and statistically significant associations of maternal caffeine intake with lower birth weight, shorter birth length, smaller head circumference and shorter gestational age.38 Of note, “similar higher risks of adverse birth outcomes were observed for the highest caffeine intake categories from coffee and tea compared with the lowest intake categories.”38

Studies in rodent models suggest that caution about coffee consumption during pregnancy (and lactation) is also warranted due to potential long-term effects on offspring that are irreversible, including adrenal abnormalities.39 A study by investigators in Turkey—famous for its “robust Turkish coffee and strong black tea”40 and where approximately 60 percent of pregnant women consume caffeine—found that administration of both low and high doses of caffeine to pregnant rats affected sex steroid levels in the fetus and neonate, leading the authors to speculate about likely effects on “behavioral and neuroendocrine functions at some point in adult life.”41

Chinese researchers, also using a rat model, found that prenatal caffeine exposure induced “high susceptibility to metabolic syndrome” in the female adult offspring.42 Metabolic syndrome is the name given to a group of risk factors for heart disease, stroke and diabetes. (The risk factors include apple-shaped obesity, high blood pressure, high blood sugar, a high triglyceride level and low HDL-cholesterol.) Somewhat confusingly, some researchers have reported that regular coffee consumption is protective for metabolic syndrome.43 However, a recent study from Finland (the country with the world’s highest per capita coffee consumption) reported that in individuals who are already type 1 diabetics, both “moderate” (three to five cups a day) and “high” (greater than five cups a day) coffee consumption was associated with increased odds of metabolic syndrome, and any level of consumption increased the risk of high blood pressure.44

A 2012 rat study out of Iran examined caffeine as a potential risk factor for male infertility, considering both in utero and lactational exposures.45 The researchers identified a number of significant long-term and dose-related effects on the “reproductive efficiency of male offspring rats,” including a decline in sperm density, decreased fetal viability and reductions in testosterone levels. A recent survey of “lifestyle causes of male infertility” cites numerous studies linking coffee and caffeine to poor semen quality, sperm DNA damage and prolonged time to pregnancy, although it is unclear whether these effects accrue solely from prior in utero exposure or also from adult caffeine consumption.46

An international childhood cancer consortium also just reported an increased risk of childhood leukemia in the children of regular coffee drinkers.47 The coffee consumption threshold beyond which the researchers detected cancer effects was two-plus cups of coffee a day.


Market reports indicate that adolescents “are drinking more coffee every year and continually starting at a younger age”— setting the stage for a life-long coffee-drinking habit.48 Teens and young adults are responding in part to clever marketing that portrays coffee drinking as “classy and sophisticated.”49 This marketing strategy appears to be paying off, because young workers between the ages of eighteen and thirty-four spend an estimated twenty-four to seventy-four dollars per week on coffee.8 The narrator of the Smithsonian’s fluff video on coffee credits entities such as Starbucks for “talking about terroir [and] making the geography of coffee available to people” and also waxes poetic about the current wave of coffee “connoisseurship” and “refinement”; the short video also features a young college student sniffing and tasting a special brew in the manner of a fine wine.12

According to the advisory committee for the 2015 Dietary Guidelines for Americans, there is a lack of consensus regarding safe levels of coffee and caffeine intake among children and adolescents.9 This may be due to the “dearth of caffeine research among younger consumers.”50 A research team in Iceland is particularly concerned about the implications of teenage caffeine consumption for long-term cardiovascular health, having found that “early exposure to caffeine may lead to persistent increases in vascular resistance, which in turn is an acknowledged risk factor for the development of hypertension.”50 Headaches are another common vascular symptom associated with coffee drinking. A study that looked at menstruation-related headaches—reported by one in four teenage girls—found that daily coffee (and cola) consumption was associated with more frequent headaches.51

Researchers have raised concerns about increased vulnerability to anxiety disorders resulting from caffeine consumption during the developmentally sensitive adolescent years. A study in rats identified “dysregulation of the neuroendocrine stress response system” following adolescent caffeine exposure, leading to “enhanced anxiety-related behavior” in adulthood.11 Disturbingly, the effects persisted into adulthood “even after removal of caffeine.”


A number of studies and meta-analyses have reported inverse (protective) associations of coffee with a variety of diseases.37 (The lead researcher of one of the more influential meta-analyses smilingly poses with a cup of coffee on his university webpage.52) The coffee lobby and even public health and medical professionals have not hesitated to use these studies to shore up their claim that “coffee is good for you.”53 (Remember when tobacco companies built relationships with academic institutions and funded scientific studies to tout the benefits of another stimulant, called nicotine? Ironically, the companies’ public relations campaigns “often [minimized] nicotine’s health risks by comparing it to caffeine or coffee”!54)

Much of the coffee-is-beneficial research is actually of a mixed-message nature. For example, one study describes coffee as a risk factor for type 1 diabetes and rheumatoid arthritis but suggests that it is protective for multiple sclerosis and autoimmune liver disease.55 Another study links coffee to an increased risk of breast cancer (among premenopausal and normal-weight women) but a reduced risk of endometrial cancer.56 A study looking at kidney cancer found that decaffeinated coffee consumption was associated with an increased risk of “aggressive” kidney cancer, while caffeinated coffee intake apparently reduced the risk57—even though other work has pointed to caffeine as a kidney toxin.58 And some investigators deny any coffee-associated cardiovascular disease risk at all,10 while others point to likely interactions with genetics, suggesting that some individuals may be genetically “predisposed” toward coffee-induced high blood pressure.59 (Does this portend a genetic test for would-be coffee drinkers?)

Is it worth running the risk of losing a pregnancy, damaging one’s adrenal system or impairing nutrient availability to obtain coffee’s purported mixed benefits? A Wise Traditions lifestyle that emphasizes a properly prepared nutrient-dense diet, adequate sunlight, time in nature, protection from cell phones and cell towers, and avoidance of toxic pharmaceutical products will go much further toward supporting good health than gambling a ride on the coffee roller coaster.


When considering what coffee does to humans, we should not overlook what coffee production is capable of doing to the environment. Traditionally, coffee was shade-grown under a diverse canopy of native trees that allowed for a “rich web of plant and animal life,” providing corridors for migrating birds, support for pollinators and “ecosystem services” that stabilized and replenished soil.60 These practices were especially important given that coffee-growing regions are home to some of the planet’s most delicate ecosystems.61 In the 1970s, industry-favorable agricultural policies and coffee’s popularity prompted a shift toward sun-grown coffee produced in plantations with no canopy—this has resulted in massive deforestation, loss of biodiversity, widespread use of toxic chemical fertilizers and soil depletion.60

Intensive agrochemical coffee production relies on an assortment of chemicals with unpronounceable names (such as ametryne, cyproconazole, diuron, epoxiconazole, flutriafol, triadimenol and triazophos), which contaminate both surface water and groundwater62 and create both acute and long-term health risks for farmworkers.63 Residues from these chemicals also pose risks to the end consumer, with “large variations in the stability of pesticide residues” depending on the processing method used.64

Although organically grown, shade-grown and fairtrade coffees have increased in popularity in the U.S., now accounting for 37 percent of American coffee sales by volume, these “specialty coffees” are still swimming against the tide in the global marketplace.60 In fact, a 2014 study reported a worldwide shift toward more intensive coffee farming over the past two decades.65 Although total global production of shade-grown coffee increased over the time period in question, “the area of land used for non shade coffee…increased at a much faster rate, resulting in shade grown coffee falling from 43 percent of total cultivated area to 24 percent”—despite “two decades of growth in public awareness of where coffee comes from and the different ways to manage it for biodiversity.”60


Consumers who make a habit of drinking the fancy coffee concoctions on offer in places like Starbucks would do well to become familiar with some of the unhealthy ingredients used by these establishments. Joan Salge Blake of Boston University says, “So much is added to [coffee]—the cream, the sugar, the flavoring—that now what people are drinking is almost like a sweetened, creamy beverage with a coffee flavoring to it.”12

According to the Food Babe (a blogger “hot on the trail to investigate what’s really in your food!”), Starbucks uses “Monsanto Milk” (non-organic milk “from farms where the cows are almost always fed a diet that consists primarily of GMO feed. . . that is laden with pesticides”) or dairy-free “milks” that are full of dubious additives such as carrageenan and guar gum.66 The Food Babe also reports that even “taking the milk out of the equation, most of the drinks at Starbucks are still filled with a ton of sugar [including high fructose corn syrup], natural flavors, preservatives, thickeners, emulsifiers and other artificial additives.”


HOT MOLASSES DRINK: 1 tablespoon molasses, 1 tablespoon coconut oil, 1/4 teaspoon powdered ginger in a mug with enough hot water to fill the mug.

CHICKEN BROTH WITH COCONUT MILK: 1 quart homemade chicken broth, 1 can full-fat coconut milk, juice of 1-2 limes, pinch of red pepper flakes.

>WARM FLAVORED MILK: 2 cups whole raw milk, 1 teaspoon vanilla extract, 1/2 teaspoon chocolate extract, 1 tablespoon carob powder, 2-3 teaspoons maple sugar. Use a whisk to blend all ingredients in a glass pyrex measuring pitcher. Set in simmering water until warm to the touch.


1. Cappelletti S, Daria P, Sani G, Aromatario M. Caffeine: cognitive and physical performance enhancer or psychoactive drug? Curr Neuropharmacol 2015;13(1):71-88.

2. Avey T. The caffeinated history of coffee. The History Kitchen, Apr. 8, 2013.

3. Goldschein E. 11 incredible facts about the global coffee industry. Business Insider, Nov. 14, 2011.

4. “What’s new: record exports in coffee year 2017/18.”

5. “Starbucks Coffee International.”




9. Drewnowski A, Rehm CD. Sources of caffeine in diets of US children and adults: trends by beverage type and purchase location. Nutrients 2016;8(3):154.

10. Nieber K. The impact of coffee on health. Planta Med 2017;83(16):1256-63.

11. O’Neill CE, Newsom RJ, Stafford J, et al. Adolescent caffeine consumption increases adulthood anxiety-related behavior and modifies neuroendocrine signaling. Psychoneuroendocrinology 2016;67:40-50.

12. “The history of coffee culture in America.”

13. Schreiner CM, Zimmerman EF, Wee EL, Scott WJ Jr. Caffeine effects on cyclic AMP levels in the mouse embryonic limb and palate in vitro. Teratology 1986;34(1):21-7.

14. Ramos B. Your brain on coffee: how caffeine affects brain chemistry. I Need Coffee, Dec. 15, 2015.

15. “Stimulant.”

16. Angelone A. Your morning coffee and adrenal imbalances. Thyroid Nation, Aug. 2, 2014.

17. Bradberry T. Caffeine: the silent killer of success. Forbes, Aug. 21, 2012.

18. Williams LL. Radical Medicine: Profound Intervention in a Profoundly Toxic Age. San Francisco, CA: International Medical Arts Publishing; 2007-2008, p. 247.

19. Todd T. Is decaffeinated or decaf coffee healthy? SteadyHealth, Jan. 7, 2009.

20. “What are methylxanthines?”

21. Desjardins N. The impact of coffee on your adrenal glands.

22. “The impact of caffeine on your adrenal glands.”

23. Lyke K. The HPA axis. Wise Traditions 2017;18(4):13-24.

24. Group E. Does coffee harm your gut? Global Healing Center, Feb. 9, 2017.

25. Hyland-Tassava S. Does coffee deplete nutrients?, Oct. 3, 2017.

26. Rapuri PB, Gallagher JC, Kinyamu HK, Ryschon KL. Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes. Am J Clin Nutr 2001;74(5):694-700.

27. Vondracek SF, Hansen LB, McDermott MT. Osteoporosis risk in premenopausal women. Pharmacotherapy 2009;29(3):305-17.

28. Zhernakova A, Kurilshikov A, Bonder MJ, et al. Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity. Science 2016;352(6285):565-9.

29. Netburn D, Healy M. Wine and coffee lovers, drink up! It’s great for your microbiome. Los Angeles Times, Apr. 29, 2016.

30. Vilanova C, Iglesias A, Porcar M. The coffee-machine bacteriome: biodiversity and colonisation of the wasted coffee tray leach. Sci Rep 2015;5:17163.

31. Intagliata C. Espresso machines brew a microbiome of their own. Scientific American, Dec. 1, 2015.

>32. Rainey C. Pod people: Nespresso’s push to become high-end restaurants’ go-to coffee. Grub Street, Mar. 21, 2013.

33. Turnbull D, Rodricks JV, Mariano GF, Chowdhury F. Caffeine and cardiovascular health. Regul Toxicol Pharmacol 2017;89:165-85.

34. Temple JL, Bernard C, Lipschultz SE, Czachor JD, Westphal JA, Mestre MA. The safety of ingested caffeine: a comprehensive review. Front Psychiatry 2017;8:80.

35. Grosso G, Godos J, Galvano F, Giovannucci EL. Coffee, caffeine, and health outcomes: an umbrella review. Annu Rev Nutr 2017;37:131-56.

36. Eskenazi B, Stapleton AL, Kharrazi M, Chee WY. Associations between maternal decaffeinated and caffeinated coffee consumption and fetal growth and gestational duration. Epidemiology 1999;10(3):242-9.

37. Poole R, Kennedy OJ, Roderick P, Fallowfield JA, Hayes PC, Parkes J. Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes. BMJ 2017;359:j5024.

38. Chen LW, Fitzgerald R, Murrin CM, et al. Associations of maternal caffeine intake with birth outcomes: results from the Lifeways Cross Generation Cohort Study. Am J Clin Nutr 2018 Oct. 19.

39. He Z, Zhu C, Huang H, et al. Prenatal caffeine exposure-induced adrenal developmental abnormality in male offspring rats and its possible intrauterine programming mechanisms. Toxicol Res (Camb) 2016;5(2):388-98.

40. Taviloglu E. Turkish tea and coffee culture: in Turkey, drinking tea and coffee is a way of life. The Spruce Eats, May 14, 2018.

41. Karaismailoglu S, Tuncer M, Bayrak S, Erdogan G, Ergun El, Erdem A. The perinatal effects of maternal caffeine intake on fetal and neonatal brain levels of testosterone, estradiol, and dihydrotestosterone in rats. Naunyn Schmiedebergs Arch Pharmacol 2017;390(8):827-38.

42. Pei LG, Yuan C, Guo YT, et al. Prenatal caffeine exposure induced high susceptibility to metabolic syndrome in adult female offspring rats and its underlying mechanisms. Reprod Toxicol 2017;71:150-8.

43. Kim JH, Park YS, Kim H. Association between metabolic syndrome and coffee consumption in the Korean population by gender: a cross-sectional study in Korea. Asia Pac J Clin Nutr 2018;27(5):1131-40.

44. Stutz B, Ahola AJ, Harjutsalo V, Forsblom C, Groop PH, FinnDiane Study Group. Association between habitual coffee consumption and metabolic syndrome in type 1 diabetes. Nutr Metab Cardiovasc Dis 2018;28(5):470-6.

45. Dorostghoal M, Erfani Majd N, Norraei P. Maternal caffeine consumption has irreversible effects on reproductive parameters and fertility in male offspring rats. Clin Exp Reprod Med 2012;39(4):144-52.

46. Durairajanayagam D. Lifestyle causes of male infertility. Arab J Urol 2018;16(1):10-20.

47. Milne E, Greenop KR, Petridou E, et al. Maternal consumption of coffee and tea during pregnancy and risk of childhood ALL: a pooled analysis from the childhood Leukemia International Consortium. Cancer Causes Control 2018;29(6):539-550.

48. “Teenagers and coffee—caffeine and your teen.”


50. James JE, Baldursdottir B, Johannsdottir KR, Valdimarsdottir HB, Sigfusdottir ID. Adolescent habitual caffeine consumption and hemodynamic reactivity during rest, psychosocial stress, and recovery. J Psychosom Res 2018;110:16-23.

51. Carman KB, Arslantas D, Unsal A, et al. Menstruation-related headache in adolescents: point prevalence and associated factors. Pediatr Int 2018;60(6):576-80.


53. Park A. 3 reasons why coffee is so good for you. TIME, Nov. 22, 2017.

54. Ling PM, Glantz SA. Tobacco company strategies to identify and promote the benefits of nicotine. Tob Control 2018 Aug. 9.

55. Anaya JM, Restrepo-Jiménez P, Ramírez-Santana C. The autoimmune ecology: an update. Curr Opin Rheumatol 2018;30(4):350-60.

56. Arthur R, Kirsh VA, Rohan TE. Associations of coffee, tea and caffeine intake with risk of breast, endometrial and ovarian cancer among Canadian women. Cancer Epidemiol 2018;56:75-82.

57. Antwi SO, Eckel-Passow JE, Diehl ND, et al. Coffee consumption and risk of renal cell carcinoma. Cancer Causes Control 2017;28(8):857-66.

58. Cosola C, Sabatino A, di Bari I, Fiaccadori E, Gesualdo L. Nutrients, nutraceuticals, and xenobiotics affecting renal health. Nutrients 2018;10(7):808.

59. Miranda AM, Steluti J, Norde MM, Fisberg RM, Marchioni DM. The association between genetic risk score and blood pressure is modified by coffee consumption: gene-diet interaction analysis in a population-based study. Clin Nutr 2018 Aug. 4.

60. Airhart MG. Shade grown coffee shrinking as a proportion of global coffee production. University of Texas College of Natural Sciences, Apr. 16, 2014.

61. Blacksell G. How green is your coffee? The Guardian, Oct 4, 2011.

62. De Queiroz VT, Azevedo MM, da Silva Quadros IP, et al. Environmental risk assessment for sustainable pesticide use in coffee production. J Contam Hydrol 2018;219:18-27.

63. Hutter HP, Khan AW, Lemmerer K, Wallner P, Kundi M, Moshammer H. Cytotoxic and genotoxic effects of pesticide exposure in male coffee farmworkers of the Jarabacoa region, Dominican Republic. Int J Environ Res Public Health 2018;15(8). Pii:E1641.

64. Chen Z, Song S, Mao L, et al. Determinations of dinotefuran and metabolite levels before and after household coffee processing in coffee beans using solid-phase extraction coupled with liquid chromatography-tandem mass spectrometry. J Sci Food Agric 2018 Aug. 2.

65. Jha S, Bacon CM, Philpott SM, Méndez VE, Läderach P, Rice RA. Shade coffee: update on a disappearing refuge for biodiversity. BioScience 2014;64(5):416-28.

66. “Starbucks finally publishes drink ingredient list… Here are the worst ones!”

This article appeared in Wise Traditions in Food, Farming and the Healing Arts, the quarterly journal of the Weston A. Price Foundation, Winter 2018

Cuppa Joe or Cuppa Jolt? Why You Should Avoid Coffee